Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease

Neurology. 1991 Feb;41(2 ( Pt 1)):202-5. doi: 10.1212/wnl.41.2_part_1.202.


We evaluated whether patients with young-onset Parkinson's disease (PD) (onset between 21 and 40 years) develop levodopa-induced dyskinesias and motor response fluctuations more frequently and earlier than patients with older-onset PD (onset after 40 years) by determining the period from levodopa introduction to development of dyskinesias or fluctuations in 25 young-onset (mean age at onset, 33.54 years) and in 25 matched older-onset PD patients (mean age at onset, 55.76 years). Young-onset PD patients had significantly higher frequency for both dyskinesias and fluctuations after both 3 and 5 years of levodopa. Young-onset PD patients also developed both levodopa-induced dyskinesias and fluctuations earlier than older-onset PD patients. We suggest that the introduction of levodopa therapy in patients with young onset PD should be postponed as long as possible.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aging / physiology*
  • Dyskinesia, Drug-Induced*
  • Humans
  • Levodopa / adverse effects*
  • Levodopa / therapeutic use
  • Middle Aged
  • Movement*
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Probability
  • Severity of Illness Index
  • Time Factors


  • Levodopa