An Efficient Method for the N-bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

Molecules. 2009 Oct 9;14(10):3952-63. doi: 10.3390/molecules14103952.

Abstract

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different beta-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemical synthesis*
  • Bromosuccinimide / chemistry*
  • Catalysis
  • Indole Alkaloids / chemical synthesis*
  • Indoles / chemical synthesis*

Substances

  • Alkanes
  • Indole Alkaloids
  • Indoles
  • Bromosuccinimide