Human genetics illuminates the paths to metabolic disease

Nature. 2009 Nov 19;462(7271):307-14. doi: 10.1038/nature08532.


Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Obesity / genetics*
  • Obesity / physiopathology


  • Insulin