Applications of platelet-rich fibrin matrix in facial plastic surgery

Facial Plast Surg. 2009 Nov;25(4):270-6. doi: 10.1055/s-0029-1242033. Epub 2009 Nov 18.


Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago. However, interest waned due to expense, amount of blood required, equipment, space, and staff needed, and lack of clinically significant benefit. A novel, simple method of preparing an autologous platelet derivative (Selphyl; Aesthetic Factors, Princeton, NJ) allows rapid and inexpensive generation of a platelet-rich fibrin matrix (PRFM) that can be used to enhance healing after facial procedures as well as to rejuvenate the face without tissue manipulation. PRFM provides autologous, natural, but concentrated platelet growth factor release and stimulation of surrounding tissue. This article describes its use for cosmetic facial applications.

MeSH terms

  • Adipose Tissue / transplantation
  • Biocompatible Materials / therapeutic use
  • Blood Platelets / physiology*
  • Cytapheresis
  • Face / surgery*
  • Female
  • Fibrin / therapeutic use*
  • Humans
  • Injections, Subcutaneous
  • Intercellular Signaling Peptides and Proteins / therapeutic use
  • Male
  • Platelet-Rich Plasma
  • Prostheses and Implants
  • Reconstructive Surgical Procedures / methods*
  • Rejuvenation
  • Skin Aging / pathology
  • Wound Healing / drug effects


  • Biocompatible Materials
  • Intercellular Signaling Peptides and Proteins
  • Fibrin