Heart diseases in mitochondrial encephalomyopathy, lactic acidosis, and stroke syndrome

Congest Heart Fail. Nov-Dec 2009;15(6):284-7. doi: 10.1111/j.1751-7133.2009.00108.x.

Abstract

Mitochondrial encephalomyopathy, lactic acidosis, and stroke (MELAS) syndrome is a mitochondrial genetic disorder caused by a point mutation, resulting in the substitution of guanine for adenine at nucleotide 3243 (A3243G) of mitochondrial DNA. This disease is characterized by a multisystem disorder with variable manifestations. The authors review heart involvement in this disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomyopathies / complications
  • Cardiomyopathies / genetics
  • Cardiomyopathies / pathology
  • DNA, Mitochondrial / physiology
  • Diagnosis, Differential
  • Heart Diseases / complications*
  • Heart Diseases / genetics
  • Humans
  • Hypertrophy, Left Ventricular / complications
  • Hypertrophy, Left Ventricular / genetics
  • MELAS Syndrome / complications*
  • MELAS Syndrome / genetics
  • MELAS Syndrome / therapy
  • Point Mutation
  • Risk Factors
  • Wolff-Parkinson-White Syndrome / complications
  • Wolff-Parkinson-White Syndrome / genetics

Substances

  • DNA, Mitochondrial