Biomarkers of disease activity, cure, and relapse in tuberculosis

Clin Chest Med. 2009 Dec;30(4):783-96, x. doi: 10.1016/j.ccm.2009.08.008.


The changing face of tuberculosis, with epidemics fueled by HIV and urbanization in much of the world and a relative increase in the importance of latent tuberculosis as a source of cases in the more economically developed countries, has led to a demand for more robust, clinically applicable diagnostic tools. As a result, research aiming to identify biomarkers of Mycobacterium tuberculosis infection and disease has flourished. This article discusses the most recent findings of that work.

Publication types

  • Review

MeSH terms

  • Antibodies, Bacterial / analysis*
  • Biomarkers / metabolism*
  • Cytokines / metabolism*
  • Diagnosis, Differential
  • Humans
  • Mycobacterium tuberculosis / immunology*
  • Tuberculin Test / methods*
  • Tuberculosis / diagnosis*
  • Tuberculosis / metabolism


  • Antibodies, Bacterial
  • Biomarkers
  • Cytokines