Gray matter abnormalities in Internet addiction: a voxel-based morphometry study

Eur J Radiol. 2011 Jul;79(1):92-5. doi: 10.1016/j.ejrad.2009.10.025. Epub 2009 Nov 18.


Background: This study aims to investigate brain gray matter density (GMD) changes in adolescents with Internet addiction (IA) using voxel-based morphometry (VBM) analysis on high-resolution T1-weighted structural magnetic resonance images.

Methods: Eighteen IA adolescents and 15 age- and gender-matched healthy controls took part in this study. High-resolution T1-weighted magnetic resonance imaging scans were performed on the two groups. VBM analysis was used to compare the GMD between the two groups.

Results: Compared with healthy controls, IA adolescents had lower GMD in the left anterior cingulate cortex, left posterior cingulate cortex, left insula, and left lingual gyrus.

Conclusions: Our findings suggested that brain structural changes were present in IA adolescents, and this finding may provide a new insight into the pathogenesis of IA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Behavior, Addictive* / epidemiology
  • Brain / pathology*
  • Case-Control Studies
  • China / epidemiology
  • Female
  • Gyrus Cinguli / pathology
  • Humans
  • Image Interpretation, Computer-Assisted
  • Incidence
  • Internet*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Surveys and Questionnaires