Intracellular calcium signalling in Alzheimer's disease

J Cell Mol Med. 2010 Jan;14(1-2):30-41. doi: 10.1111/j.1582-4934.2009.00976.x. Epub 2009 Nov 19.


More than two decades ago, dysregulation of the intracellular Ca(2+) homeostasis was suggested to underlie the development of Alzheimer's disease (AD). This hypothesis was tested in numerous in vitro studies, which revealed multiple Ca(2+) signalling pathways able to contribute to AD pathology. It remained, however, unclear whether these pathways are also activated in vivo, in cells involved in signal processing in the living brain. Here we review recent data analysing intracellular Ca(2+) signalling in vivo in the context of previous in vitro findings. We particularly focus on the processes taking place in the immediate vicinity of amyloid plaques and on their possible role for AD-mediated brain dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Calcium / metabolism*
  • Calcium Signaling / physiology*
  • Homeostasis
  • Humans
  • Neurofibrillary Tangles / pathology
  • Presenilins / genetics
  • Presenilins / metabolism
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Synapses / metabolism


  • Amyloid beta-Peptides
  • Presenilins
  • Protein Isoforms
  • Calcium