Promoting axonal rewiring to improve outcome after stroke

Neurobiol Dis. 2010 Feb;37(2):259-66. doi: 10.1016/j.nbd.2009.11.009. Epub 2009 Nov 26.


A limited amount of functional recovery commonly occurs in the weeks and months after stroke, and a number of studies show that such recovery is associated with changes in the brain's functional organization. Measures that augment this reorganization in a safe and effective way may therefore help improve outcome in stroke patients. Here we review some of the evidence for functional and anatomical reorganization under normal physiological conditions, along with strategies that augment these processes and improve outcome after brain injury in animal models. These strategies include counteracting inhibitors of axon growth associated with myelin, activating neurons' intrinsic growth state, enhancing physiological activity, and having behavioral therapy. These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior Therapy / methods
  • Behavior Therapy / standards
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / physiopathology
  • Disease Models, Animal
  • Growth Cones / drug effects*
  • Growth Cones / physiology
  • Growth Inhibitors / antagonists & inhibitors
  • Humans
  • Inosine / pharmacology
  • Inosine / therapeutic use
  • Nerve Growth Factors / pharmacology
  • Nerve Growth Factors / therapeutic use
  • Neuronal Plasticity / drug effects*
  • Neuronal Plasticity / physiology
  • Recovery of Function / drug effects*
  • Recovery of Function / physiology
  • Stroke / metabolism
  • Stroke / physiopathology
  • Stroke / therapy*


  • Growth Inhibitors
  • Nerve Growth Factors
  • Inosine