The emergence of new genes on the young therian X

Lukasz Potrzebowski; Nicolas Vinckenbosch; Henrik Kaessmann

doi:10.1016/j.tig.2009.11.001

The emergence of new genes on the young therian X

Trends Genet. 2010 Jan;26(1):1-4. doi: 10.1016/j.tig.2009.11.001. Epub 2009 Nov 20.

Authors

Lukasz Potrzebowski¹, Nicolas Vinckenbosch, Henrik Kaessmann

Affiliation

¹ Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.

PMID: 19931933
DOI: 10.1016/j.tig.2009.11.001

Abstract

Recent studies have revealed that our sex chromosomes differentiated relatively recently from ancestral autosomes in the common ancestor of placental and marsupial mammals (therians). Here, we show that the therian X started to accumulate new retroduplicate genes with overall sex-biased expression upon therian sex chromosome differentiation. This process reached its peak within the first approximately 90 million years of sex chromosome evolution and then leveled off. Taken together, our observations suggest that the major sex-related functional remodeling of the X was completed relatively soon after the origination of therian sex chromosomes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging*
Animals
Evolution, Molecular
Gene Expression Regulation
Humans
Mammals / genetics*
X Chromosome*