Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)

Bioorg Med Chem Lett. 2010 Jan 1;20(1):180-3. doi: 10.1016/j.bmcl.2009.11.004. Epub 2009 Nov 10.

Abstract

From our modulator library an interesting inhibitor of breast cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters / antagonists & inhibitors*
  • ATP-Binding Cassette Transporters / metabolism
  • Benzamides / chemical synthesis
  • Benzamides / chemistry*
  • Benzamides / pharmacology
  • Benzimidazoles / metabolism
  • Cell Line, Tumor
  • Chlorophyll / analogs & derivatives
  • Chlorophyll / metabolism
  • Humans
  • Molecular Conformation
  • Neoplasm Proteins / antagonists & inhibitors*
  • Neoplasm Proteins / metabolism
  • Phenylurea Compounds / chemical synthesis
  • Phenylurea Compounds / chemistry*
  • Phenylurea Compounds / pharmacology
  • Small Molecule Libraries

Substances

  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Benzamides
  • Benzimidazoles
  • Neoplasm Proteins
  • Phenylurea Compounds
  • Small Molecule Libraries
  • Chlorophyll
  • pheophorbide a
  • bisbenzimide ethoxide trihydrochloride