Abstract
From our modulator library an interesting inhibitor of breast cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters / antagonists & inhibitors*
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ATP-Binding Cassette Transporters / metabolism
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Benzamides / chemical synthesis
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Benzamides / chemistry*
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Benzamides / pharmacology
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Benzimidazoles / metabolism
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Cell Line, Tumor
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Chlorophyll / analogs & derivatives
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Chlorophyll / metabolism
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Humans
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Molecular Conformation
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Neoplasm Proteins / antagonists & inhibitors*
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Neoplasm Proteins / metabolism
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Phenylurea Compounds / chemical synthesis
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Phenylurea Compounds / chemistry*
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Phenylurea Compounds / pharmacology
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Small Molecule Libraries
Substances
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ABCG2 protein, human
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters
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Benzamides
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Benzimidazoles
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Neoplasm Proteins
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Phenylurea Compounds
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Small Molecule Libraries
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Chlorophyll
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pheophorbide a
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bisbenzimide ethoxide trihydrochloride