Estrogen and Xenoestrogens in Breast Cancer

Toxicol Pathol. 2010 Jan;38(1):110-22. doi: 10.1177/0192623309354108. Epub 2009 Nov 21.

Abstract

There is growing concern that estrogenic environmental compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fueled by evidence indicating that natural estrogens, specifically 17beta-estradiol, are important factors in the initiation and progression of breast cancer. We have developed an in vitro-in vivo model in which we have demonstrated the carcinogenicity of E2 in human breast epithelial cells MCF-10F. Hypermethylation of NRG1, STXBP6, BMP6, CSS3, SPRY1, and SNIP were found at different progression stages in this model. The use of this powerful and unique model has provided a tool for exploring whether bisphenol A and butyl benzyl phthalate have relevance in the initiation of breast cancer. These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Benzhydryl Compounds
  • Breast Neoplasms / chemically induced*
  • Cell Transformation, Neoplastic / chemically induced*
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases / analysis
  • DNA Methylation
  • Epigenesis, Genetic
  • Estradiol / toxicity*
  • Female
  • Gene Silencing
  • Humans
  • Phenols / toxicity*
  • Phthalic Acids / toxicity*

Substances

  • Benzhydryl Compounds
  • Phenols
  • Phthalic Acids
  • Estradiol
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA methyltransferase 3A
  • bisphenol A
  • butylbenzyl phthalate