Mini-review: Management of hypoglycaemia in children aged 0-59 months

J Trop Pediatr. 2010 Aug;56(4):227-34. doi: 10.1093/tropej/fmp109. Epub 2009 Nov 23.


Hypoglycaemia is associated with poor prognosis in many severe childhood illnesses especially in sub-Saharan Africa where the prevalence of malaria, diarrhoea and malnutrition remains high. Uncertainty, however, still persists regarding the significance, definition and management of childhood hypoglycaemia. As a step towards defining optimal, evidence-based diagnostic and management criteria, we (i) reviewed the evidence underlying current recommendations for the management of hypoglycaemia, and (ii) analysed a large set of data on blood glucose levels and associated outcomes of paediatric admissions in a rural hospital over an 11-year period. Current definitions and treatment protocols for hypoglycaemia are based on observational data and expert opinion. Future large pragmatic randomized trials would help define optimal treatment thresholds. Emerging evidence suggests that sublingual sugar is a feasible and effective therapy for correction of hypoglycaemia, and should be considered where intravenous glucose is delayed or impossible.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Glucose / analysis*
  • Child, Preschool
  • Female
  • Glucose / administration & dosage
  • Glucose / therapeutic use*
  • Humans
  • Hypoglycemia / drug therapy*
  • Hypoglycemia / epidemiology
  • Incidence
  • Infant
  • Infant, Newborn
  • Infusions, Intravenous
  • Kenya / epidemiology
  • Prevalence
  • Randomized Controlled Trials as Topic
  • Retrospective Studies
  • Treatment Outcome


  • Blood Glucose
  • Glucose