Chloroplast transit peptides. The perfect random coil?

FEBS Lett. 1991 Jan 14;278(1):1-3. doi: 10.1016/0014-5793(91)80069-f.


Structural analysis of chloroplast transit peptides (cTPs), including secondary structure prediction and analysis of 'cTP-like' peptides of known 3D structure, suggests that cTPs are essentially flexible peptides devoid of regular secondary or tertiary structure. It is proposed that cTPs may be designed to interact with a succession of different chaperones on the chloroplast protein-import pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chloroplasts / metabolism*
  • Molecular Sequence Data
  • Plant Proteins / genetics*
  • Protein Conformation
  • Sequence Homology, Nucleic Acid


  • Plant Proteins