The microRNA network and tumor metastasis

Oncogene. 2010 Feb 18;29(7):937-48. doi: 10.1038/onc.2009.406. Epub 2009 Nov 23.


Metastasis is the most significant process affecting the clinical management of cancer patients and occurs in multiple sequential steps. However, the molecular pathways underlying each step still remain obscure. Recent research has shown that there is a microRNA (miRNA) network that functions as a regulator of tumor metastasis. In this paper, we review the role of miRNAs in tumor metastasis, including control of epithelial-mesenchymal transition, regulation of metastasis-associated genes and epigenetic alterations. More information on miRNAs will promote a better understanding of the molecular mechanism of metastasis.

Publication types

  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Genes, Neoplasm / genetics
  • Humans
  • Mesoderm / metabolism
  • Mesoderm / pathology
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Neoplasm Metastasis / genetics*
  • Neoplasm Metastasis / pathology*


  • MicroRNAs