Abstract
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
Publication types
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Comment
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News
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Axons / physiology*
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Cell Differentiation / physiology
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Dendrites / physiology*
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Drosophila / growth & development
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Drosophila / physiology*
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Metamorphosis, Biological / physiology
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Neurons / physiology*
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Neurons / ultrastructure
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SOXB2 Transcription Factors / genetics
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SOXB2 Transcription Factors / metabolism*
Substances
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Drosophila Proteins
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SOXB2 Transcription Factors
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Sox14 protein, Drosophila