Neuronal death or dismemberment mediated by Sox14

Nat Neurosci. 2009 Dec;12(12):1479-80. doi: 10.1038/nn1209-1479.

Abstract

The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.

Publication types

  • Comment
  • News
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology*
  • Cell Differentiation / physiology
  • Dendrites / physiology*
  • Drosophila / growth & development
  • Drosophila / physiology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Metamorphosis, Biological / physiology
  • Neurons / physiology*
  • Neurons / ultrastructure
  • SOXB2 Transcription Factors / genetics
  • SOXB2 Transcription Factors / metabolism*

Substances

  • Drosophila Proteins
  • SOXB2 Transcription Factors
  • Sox14 protein, Drosophila