Tissue-mediated control of immunopathology in coeliac disease

Nat Rev Immunol. 2009 Dec;9(12):858-70. doi: 10.1038/nri2670.


Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation--induced either by infectious agents or by gluten--is crucial for activating T cells and eliciting their tissue-destructive effector functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Genetic Predisposition to Disease
  • Glutens / immunology
  • Humans
  • Inflammation / immunology
  • Lymphocyte Activation / immunology*
  • T-Lymphocytes / immunology*


  • Glutens