Intravesical lignocaine in the diagnosis of bladder pain syndrome

Int Urogynecol J. 2010 Mar;21(3):321-4. doi: 10.1007/s00192-009-1045-0.


Introduction and hypothesis: To differentiate between the pain originating from urinary bladder and that due to other pelvic organs, using intravesical instillations of 2% lignocaine solution.

Methods: Twenty-two women with pelvic pain received intravesical instillation of 20 ml of 2% lignocaine solution. The intensity of pain was recorded by using visual analogue scale (VAS) just before, at 2, 10 and 20 min after intravesical instillation. Women who experienced a drop in the VAS score by 50% were termed as responders. All these women underwent cystoscopy under anaesthesia.

Results: Fifteen out of 22 (68.18%) women experienced a substantial reduction in the pain. Thirteen out of these 15 women had features suggestive of BPS/IC on cystoscopy. Out of the seven non-responders, two women were found to have endometriosis, four were diagnosed as pelvic inflammatory disease and one had diverticulitis.

Conclusions: Intravesical lignocaine appears to be useful in excluding patients with pelvic pain originating from organs other than the urinary bladder.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Intravesical
  • Adult
  • Anesthetics, Local*
  • Cystitis, Interstitial / diagnosis*
  • Female
  • Humans
  • Lidocaine*
  • Middle Aged
  • Young Adult


  • Anesthetics, Local
  • Lidocaine