The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix

Cell Mol Biol Lett. 2010;15(1):98-117. doi: 10.2478/s11658-009-0037-x. Epub 2009 Nov 20.

Abstract

In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine / chemistry
  • Calorimetry, Differential Scanning
  • Dimyristoylphosphatidylcholine / chemistry
  • Fluorescent Dyes / chemistry
  • Gossypol / analogs & derivatives*
  • Gossypol / chemistry
  • Gossypol / metabolism
  • Lipid Bilayers / chemistry
  • Liposomes / chemistry*
  • Liposomes / metabolism
  • Povidone / chemistry*
  • Povidone / metabolism
  • Thermodynamics

Substances

  • Fluorescent Dyes
  • Lipid Bilayers
  • Liposomes
  • 1,2-Dipalmitoylphosphatidylcholine
  • Povidone
  • Gossypol
  • Dimyristoylphosphatidylcholine