Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt

Mol Cells. 2009 Dec 31;28(6):583-8. doi: 10.1007/s10059-009-0152-6. Epub 2009 Nov 19.


The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells' survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Growth Processes / physiology
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic / physiology
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology*
  • Neoplasm Invasiveness / genetics
  • Neoplasm Invasiveness / pathology
  • Oxidative Stress / genetics
  • Peroxiredoxin VI / genetics
  • Peroxiredoxin VI / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism
  • RNA, Small Interfering / genetics
  • Signal Transduction / genetics
  • Transgenes / genetics
  • Urokinase-Type Plasminogen Activator / biosynthesis*
  • Urokinase-Type Plasminogen Activator / genetics
  • p38 Mitogen-Activated Protein Kinases / metabolism


  • RNA, Small Interfering
  • PRDX6 protein, human
  • Peroxiredoxin VI
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • p38 Mitogen-Activated Protein Kinases
  • Urokinase-Type Plasminogen Activator