The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: a prospective clinical trial

Fertil Steril. 2010 Jul;94(2):761-3. doi: 10.1016/j.fertnstert.2009.10.004. Epub 2009 Nov 25.

Abstract

We compared the efficiency of progesterone vaginal gel (PVG) with intramuscular progesterone (IMP) supplementation for luteal phase support after in vitro fertilization and embryo transfer in gonadotropin-releasing hormone (GnRH) antagonist cycles. The treatment outcomes were similar for PVG and IMP for luteal support in GnRH-antagonist protocols. With its ease of use, high tolerability by patients, and fewer side effects, PVG can be a successful alternative to IMP.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Embryo Transfer
  • Female
  • Fertilization in Vitro / methods*
  • Gels
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors*
  • Humans
  • Injections, Intramuscular
  • Luteal Phase / drug effects*
  • Ovulation Induction / methods*
  • Pregnancy
  • Progesterone / administration & dosage*
  • Progestins / administration & dosage*
  • Prospective Studies

Substances

  • Gels
  • Progestins
  • Gonadotropin-Releasing Hormone
  • Progesterone