Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase

J Virol. 2010 Feb;84(4):1838-46. doi: 10.1128/JVI.01496-09. Epub 2009 Nov 25.

Abstract

Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Reaction / immunology
  • Acute-Phase Reaction / pathology
  • Animals
  • Cell Movement
  • Chlorocebus aethiops
  • Dendritic Cells / immunology*
  • Dendritic Cells / pathology
  • Inflammation / immunology
  • Inflammation / pathology
  • Interferon Type I / metabolism*
  • Interferon-alpha / metabolism
  • Interleukin-8 / metabolism
  • Lymph Nodes / immunology
  • Lymph Nodes / pathology
  • Macaca mulatta
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Acquired Immunodeficiency Syndrome / pathology
  • Simian Immunodeficiency Virus / immunology*
  • Simian Immunodeficiency Virus / pathogenicity*
  • Species Specificity
  • Toll-Like Receptor 7 / metabolism
  • Toll-Like Receptor 9 / metabolism
  • Virulence / immunology

Substances

  • Interferon Type I
  • Interferon-alpha
  • Interleukin-8
  • Toll-Like Receptor 7
  • Toll-Like Receptor 9