Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire

Qual Life Res. 2010 Feb;19(1):65-80. doi: 10.1007/s11136-009-9558-z. Epub 2009 Nov 26.


Purpose: To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.

Methods: A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.

Results: OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R(2): 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.

Conclusion: Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Analysis of Variance
  • Anti-Inflammatory Agents / administration & dosage*
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Health Status Indicators
  • Humans
  • Male
  • Mometasone Furoate
  • Otitis Media with Effusion / drug therapy*
  • Otitis Media with Effusion / psychology
  • Pregnadienediols / administration & dosage*
  • Psychometrics
  • Quality-Adjusted Life Years*
  • Reference Values
  • Severity of Illness Index
  • Sickness Impact Profile*
  • Surveys and Questionnaires*


  • Anti-Inflammatory Agents
  • Pregnadienediols
  • Mometasone Furoate