Progression through the RNA polymerase II CTD cycle

Mol Cell. 2009 Nov 25;36(4):541-6. doi: 10.1016/j.molcel.2009.10.019.


The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Promoter Regions, Genetic
  • Protein Structure, Tertiary
  • RNA Polymerase II / chemistry*
  • RNA Polymerase II / metabolism*
  • Transcription, Genetic


  • RNA Polymerase II