Timing matters

FEBS Lett. 2009 Dec 17;583(24):4013-8. doi: 10.1016/j.febslet.2009.11.065.


Cells are entities in space and time. Systems biology strives to understand their composition, structural organization as well as dynamic behavior under different conditions. Here, measures for dynamic properties such as characteristic times, time hierarchy and time-dependent response are reviewed. Using a number of examples from yeast and micro-organism systems biology, the importance of considering the timing in experimental and theoretical research is discussed.

Publication types

  • Review

MeSH terms

  • Metabolic Networks and Pathways*
  • Models, Biological*
  • Systems Biology / methods*
  • Time Factors
  • Yeasts / metabolism*