Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes

Bioorg Med Chem. 2010 Jan 1;18(1):151-7. doi: 10.1016/j.bmc.2009.11.007. Epub 2009 Nov 10.

Abstract

The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Allergic Agents / chemistry*
  • Anti-Allergic Agents / pharmacology*
  • Bees / chemistry
  • Cell Line, Tumor
  • Cysteine / immunology*
  • Histamine / immunology
  • Humans
  • Leukocytes / drug effects
  • Leukocytes / immunology
  • Leukotrienes / immunology*
  • Propolis / chemistry*
  • Propolis / pharmacology*
  • Rhinitis, Allergic, Seasonal / drug therapy*

Substances

  • Anti-Allergic Agents
  • Leukotrienes
  • cysteinyl-leukotriene
  • Histamine
  • Propolis
  • Cysteine