Thyroid hormone in cardiac surgery

Vascul Pharmacol. 2010 Mar-Apr;52(3-4):131-7. doi: 10.1016/j.vph.2009.11.004. Epub 2009 Nov 27.


Thyroid hormone has a wide range of cardiovascular effects which are mediated at both genomic and non-genomic levels. As a stress response to surgery, the non-thyroidal illness syndrome or euthyroid sick syndrome occurs in the post-operative period following cardiac surgery. There remains debate about the potential benefits of the treatment of the non-thyroidal illness syndrome in this setting with acute thyroid hormone supplementation. This review article sets out to discuss the potential benefits of thyroid hormone supplementation and the results from trials relating to both adult and paediatric cardiac surgical population as well as in the setting of brain stem death to optimise the potential cardiac donor.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Cardiac Surgical Procedures / adverse effects
  • Cardiac Surgical Procedures / methods*
  • Child
  • Clinical Trials as Topic
  • Euthyroid Sick Syndromes / drug therapy
  • Euthyroid Sick Syndromes / etiology
  • Heart Transplantation / methods
  • Humans
  • Postoperative Complications / drug therapy
  • Tissue Donors
  • Tissue and Organ Harvesting / methods
  • Triiodothyronine / pharmacology
  • Triiodothyronine / therapeutic use*


  • Triiodothyronine