Enantioselective Friedel-Crafts alkylation of pyrroles catalyzed by PYBOX-DIPH-Zn(II) complexes

Pradeep K Singh; Vinod K Singh

doi:10.1021/ol902360b

Enantioselective Friedel-Crafts alkylation of pyrroles catalyzed by PYBOX-DIPH-Zn(II) complexes

Org Lett. 2010 Jan 1;12(1):80-3. doi: 10.1021/ol902360b.

Authors

Pradeep K Singh¹, Vinod K Singh

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016.

PMID: 19947623
DOI: 10.1021/ol902360b

Abstract

A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).