The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study

Arthritis Rheum. 1991 Feb;34(2):198-203. doi: 10.1002/art.1780340211.


We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose [18FDG]). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis.

MeSH terms

  • Animals
  • Coronary Circulation / drug effects*
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / pharmacokinetics
  • Female
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Heart / drug effects
  • Humans
  • Male
  • Middle Aged
  • Myocardium / metabolism*
  • Nifedipine / adverse effects
  • Nifedipine / therapeutic use*
  • Potassium Radioisotopes
  • Scleroderma, Systemic / diagnostic imaging*
  • Scleroderma, Systemic / drug therapy*
  • Scleroderma, Systemic / metabolism
  • Tomography, Emission-Computed


  • Fluorine Radioisotopes
  • Potassium Radioisotopes
  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Nifedipine