Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A placebo-controlled study

Am J Phys Med Rehabil. 1991 Feb;70(1):29-33. doi: 10.1097/00002060-199102000-00006.


This study was designed to investigate the effects of a new product of counterirritant, Eucalyptamint, on the cutaneous circulation and on skin and muscle temperatures. Ten normal subjects (six males and four females, with an average age of 34 +/- 6 yr) were involved in this study. Eucalyptamint was applied to the anterior forearm skin of one side, and placebo was applied to the contralateral forearm. The subjective feelings, cutaneous blood flow, and skin temperature were measured before and periodically (5-min intervals) after the application of the compound. Muscle temperature was measured before and 30 min after the application of the Eucalyptamint. There was no significant effect on the subjective sensation. However, there were statistically significant (P less than 0.05) increases in cutaneous blood flow (up to 4 times base-line) and skin temperatures (up to 0.8 degrees C higher than base-line) after the application of Eucalyptamint with the effects lasting up to 45 min after the application. The muscle temperature was also increased (0.4 degrees C) significantly (P less than 0.05) 30 min after application of the Eucalyptamint. There were no significant changes in the placebo application. The results of this study suggested that the new product of counterirritant, Eucalyptamint, produced significant physiologic responses that may be beneficial for pain relief and/or useful to athletes as a passive form of warm-up.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Blood Flow Velocity / drug effects*
  • Body Temperature / drug effects*
  • Drug Combinations
  • Eucalyptus*
  • Female
  • Humans
  • Lanolin / administration & dosage
  • Lanolin / pharmacology*
  • Lanolin / therapeutic use
  • Male
  • Menthol / administration & dosage
  • Menthol / pharmacology*
  • Menthol / therapeutic use
  • Muscles / drug effects*
  • Plants, Medicinal*
  • Skin / blood supply*
  • Skin Temperature / drug effects*


  • Drug Combinations
  • Menthol
  • Lanolin