Adenosine in fibrosis

Mod Rheumatol. 2010 Apr;20(2):114-22. doi: 10.1007/s10165-009-0251-4. Epub 2009 Dec 1.


Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regenerative responses are intricately linked, with wound healing being a prime example. It has only recently been appreciated that adenosine has a key role in tissue regenerative and fibrotic processes. An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / physiology*
  • Animals
  • Fibrosis / physiopathology*
  • Humans
  • Mice
  • Purinergic P1 Receptor Agonists
  • Receptors, Purinergic P1 / physiology*
  • Signal Transduction
  • Wound Healing / physiology


  • Purinergic P1 Receptor Agonists
  • Receptors, Purinergic P1
  • Adenosine