Utility of synovial biopsy

Arthritis Res Ther. 2009;11(6):256. doi: 10.1186/ar2847. Epub 2009 Nov 23.


Synovial biopsies, gained either by blind needle biopsy or minimally invasive arthroscopy, offer additional information in certain clinical situations where routine assessment has not permitted a certain diagnosis. In research settings, synovial histology and modern applications of molecular biology increase our insight into pathogenesis and enable responses to treatment with new therapeutic agents to be assessed directly at the pathophysiological level. This review focuses on the diagnostic usefulness of synovial biopsies in the light of actual developments.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / diagnosis*
  • Biopsy / instrumentation*
  • Biopsy / methods
  • Humans
  • Synovectomy*