Transcriptional regulation of metastatic [Id]entity by KLF17

Marcin P Iwanicki; Joan S Brugge

doi:10.1186/gb-2009-10-11-244

Transcriptional regulation of metastatic [Id]entity by KLF17

Genome Biol. 2009;10(11):244. doi: 10.1186/gb-2009-10-11-244. Epub 2009 Nov 30.

Authors

Marcin P Iwanicki¹, Joan S Brugge

Affiliation

¹ Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Abstract

A novel in vivo screening approach has identified KLF17 as a key metastasis suppressor gene that acts through regulation of Id1 transcription factor-dependent induction of the epithelial-to-mesenchymal transition.

Publication types

Review

MeSH terms

Disease Progression
Epithelium / metabolism
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
Humans
Inhibitor of Differentiation Protein 1 / metabolism
Mesoderm / metabolism
Models, Biological
Neoplasm Metastasis
Neoplasms / metabolism*
Transcription Factors / biosynthesis*
Transcription Factors / genetics*

Substances

ID1 protein, human
Inhibitor of Differentiation Protein 1
KLF17 protein, human
Transcription Factors