Pericentrin in cellular function and disease

J Cell Biol. 2010 Jan 25;188(2):181-90. doi: 10.1083/jcb.200908114. Epub 2009 Dec 1.

Abstract

Pericentrin is an integral component of the centrosome that serves as a multifunctional scaffold for anchoring numerous proteins and protein complexes. Through these interactions, pericentrin contributes to a diversity of fundamental cellular processes. Recent studies link pericentrin to a growing list of human disorders. Studies on pericentrin at the cellular, molecular, and, more recently, organismal level, provide a platform for generating models to elucidate the etiology of these disorders. Although the complexity of phenotypes associated with pericentrin-mediated disorders is somewhat daunting, insights into the cellular basis of disease are beginning to come into focus. In this review, we focus on human conditions associated with loss or elevation of pericentrin and propose cellular and molecular models that might explain them.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens / genetics
  • Antigens / metabolism*
  • Cell Death / genetics
  • Centrosome / metabolism*
  • Centrosome / ultrastructure
  • Dwarfism / genetics
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Mental Disorders / genetics
  • Microtubules / genetics
  • Microtubules / metabolism*
  • Mitosis / genetics
  • Neoplasms / genetics
  • Spindle Apparatus / genetics
  • Spindle Apparatus / metabolism*

Substances

  • Antigens
  • pericentrin