The Fisher variant of Guillain-Barré syndrome (Fisher syndrome)

J Neuroophthalmol. 2009 Dec;29(4):312-24. doi: 10.1097/WNO.0b013e3181c2514b.


Fisher syndrome (FS) is an acute polyneuropathy typically characterized by the triad of ataxia, areflexia, and ophthalmoplegia, although it may present with 2 or even just 1 of these clinical findings. Similarities between FS and other acute polyneuropathies such as Guillain-Barré syndrome (GBS) and Bickerstaff brainstem encephalitis (BBE) suggest that FS is part of a spectrum of autoimmune disorders that may affect the peripheral and/or central nervous system. Anti-GQ1b antibody is present in the serum of more than 85% of patients with FS, but it is not specific to FS. Why some patients develop FS and others develop typical GBS or one of its other variants is still largely unknown.

Publication types

  • Review

MeSH terms

  • Ataxia / physiopathology
  • Biomarkers
  • Disease Progression
  • Humans
  • Incidence
  • Miller Fisher Syndrome / diagnosis*
  • Miller Fisher Syndrome / epidemiology*
  • Miller Fisher Syndrome / physiopathology
  • Ophthalmoplegia / physiopathology


  • Biomarkers