Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival

Int J Gynecol Pathol. 2010 Jan;29(1):88-92. doi: 10.1097/PGP.0b013e3181acefbf.


Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / mortality
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / virology
  • Adult
  • Carcinoma in Situ / mortality
  • Carcinoma in Situ / pathology*
  • Carcinoma in Situ / virology
  • Female
  • Human papillomavirus 16
  • Humans
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / secondary*
  • Ovarian Neoplasms / virology
  • Papillomavirus Infections / complications
  • Pregnancy
  • Pregnancy Complications, Neoplastic / pathology
  • Pregnancy Complications, Neoplastic / virology
  • Uterine Cervical Neoplasms / mortality
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / virology