The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients

FEBS Lett. 1991 Feb 11;279(1):55-7. doi: 10.1016/0014-5793(91)80249-3.

Abstract

The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

MeSH terms

  • Aged
  • Alzheimer Disease / enzymology*
  • Blotting, Western
  • Casein Kinases
  • Cerebral Cortex / enzymology*
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Middle Aged
  • Phosphorylation
  • Protein Kinases / analysis*
  • Schizophrenia / enzymology*

Substances

  • Protein Kinases
  • Casein Kinases