Inflammasomes: too big to miss

J Clin Invest. 2009 Dec;119(12):3502-11. doi: 10.1172/JCI40599. Epub 2009 Dec 1.


Inflammation is the coordinated immune response to harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1beta.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Caspase 1 / metabolism
  • Humans
  • Immunity, Innate
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Inflammation / pathology
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Interleukin-1 / metabolism
  • Macromolecular Substances / metabolism
  • Models, Immunological
  • Receptors, Immunologic / metabolism
  • Signal Transduction / immunology


  • Adaptor Proteins, Signal Transducing
  • Inflammation Mediators
  • Interleukin-1
  • Macromolecular Substances
  • Receptors, Immunologic
  • Caspase 1