Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis

Nephron Exp Nephrol. 2010;114(3):e83-92. doi: 10.1159/000262316. Epub 2009 Dec 2.


Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.

Publication types

  • Review

MeSH terms

  • Base Sequence
  • Biomarkers / metabolism
  • Connective Tissue Growth Factor* / antagonists & inhibitors
  • Connective Tissue Growth Factor* / biosynthesis
  • Connective Tissue Growth Factor* / genetics
  • Connective Tissue Growth Factor* / physiology
  • Fibrosis
  • Gene Expression Regulation
  • Humans
  • Kidney / embryology
  • Kidney / pathology*
  • Kidney Diseases / diagnosis
  • Kidney Diseases / drug therapy
  • Kidney Diseases / pathology


  • Biomarkers
  • Connective Tissue Growth Factor