Forcing cells to change lineages

Nature. 2009 Dec 3;462(7273):587-94. doi: 10.1038/nature08533.


The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage / physiology*
  • Cellular Reprogramming / genetics*
  • Gene Expression Regulation, Developmental*
  • Gene Regulatory Networks / physiology
  • Humans
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*
  • Transcription Factors / metabolism*


  • Transcription Factors