Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 58 (2), 835-41

Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats

Affiliations

Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats

Mari Watanabe-Kamiyama et al. J Agric Food Chem.

Abstract

Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [(14)C]proline (Pro group) or glycyl-[(14)C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.

Similar articles

See all similar articles

Cited by 23 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback