Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

J Comb Chem. Jan-Feb 2010;12(1):69-74. doi: 10.1021/cc900063y.


A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Combinatorial Chemistry Techniques / methods
  • Molecular Structure
  • Pyrazolones / chemical synthesis*
  • Pyrazolones / chemistry
  • Tetrazoles / chemical synthesis*
  • Tetrazoles / chemistry


  • Pyrazolones
  • Tetrazoles