Chitosan-based nanostructures: a delivery platform for ocular therapeutics

Adv Drug Deliv Rev. 2010 Jan 31;62(1):100-17. doi: 10.1016/j.addr.2009.11.026. Epub 2009 Dec 1.


Nanoscience and nanotechnology has caused important breakthroughs in different therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led to the development of novel strategies for the treatment of ocular disorders. Indeed, the association of an active molecule to a nanocarrier allows the molecule to intimately interact with specific ocular structures, to overcome ocular barriers and to prolong its residence in the target tissue. Over the last decade, our group has designed and developed a delivery platform based on the polysaccharide chitosan, which suits the requirements of the topical ocular route. These nanosystems have been specifically adapted for the delivery of hydrophilic and lipophilic drugs and also polynucleotides onto the eye surface. The results collected up until now suggest the potential of this delivery platform and the subsequent need of a full preclinical evaluation in order to satisfy the specific regulatory demands of this mode of administration.

Publication types

  • Review

MeSH terms

  • Administration, Topical
  • Animals
  • Chitosan / administration & dosage*
  • Chitosan / pharmacokinetics
  • Drug Delivery Systems / methods*
  • Epithelium, Corneal / drug effects*
  • Epithelium, Corneal / metabolism
  • Eye Diseases / drug therapy
  • Eye Diseases / metabolism
  • Gene Transfer Techniques
  • Humans
  • Nanostructures / administration & dosage*


  • Chitosan