Modulation of matrix remodeling by SPARC in neoplastic progression

Semin Cell Dev Biol. 2010 Feb;21(1):55-65. doi: 10.1016/j.semcdb.2009.11.018. Epub 2009 Dec 1.


SPARC is a matricellular glycoprotein that mediates interactions between cells and their microenvironment. It is produced at sites of tissue remodeling, where it regulates matrix deposition and turnover, cell adhesion, and signaling by extracellular factors, exerting profound effects on tissue architecture and cell physiology. During extensive matrix remodeling in neoplastic progression, SPARC is expressed in cancer-associated stroma and in malignant cells of some types, affecting tumor development, invasion, metastases, angiogenesis and inflammation. SPARC-induced changes in the tumor microenvironment can suppress or promote progression of different cancers depending on the tissue and cell type. Understanding the mechanism of matrix remodeling and its regulation by SPARC is essential for the development of new treatment strategies for highly aggressive cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Disease Models, Animal
  • Disease Progression
  • Extracellular Matrix / metabolism*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Molecular Sequence Data
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Neoplasms* / physiopathology
  • Osteonectin / genetics
  • Osteonectin / metabolism*
  • Receptors, Cell Surface / metabolism
  • Sequence Alignment
  • Signal Transduction / physiology
  • Stromal Cells / metabolism
  • Stromal Cells / pathology


  • Intercellular Signaling Peptides and Proteins
  • Osteonectin
  • Receptors, Cell Surface