Reproducibility in echocardiographic assessment of the left ventricular global and regional function, the HUNT study

Eur J Echocardiogr. 2010 Mar;11(2):149-56. doi: 10.1093/ejechocard/jep188. Epub 2009 Dec 3.


Aims: The study aimed to compare the inter-observer reproducibility of new and traditional measurements of the left ventricular (LV) global and regional function.

Methods and results: Two experienced echocardiographers performed 20 complete echo/Doppler examinations and 50 analyses on ten healthy subjects. All recordings were analysed for systolic and diastolic conventional and deformation measurements by both echocardiographers. Inter-observer mean error (absolute difference divided by the mean) was 4% and lowest (P = 0.001) for systolic M-mode annulus excursion. Mean error for the regional deformation indices was significantly higher than for all the global measurements (all P < 0.001). Mean error for analyses of the same recording was 34% (P = 0.002) lower for global systolic indices and 44% (P < 0.001) lower for global diastolic indices than inter-observer mean error for analyses made in separate recordings.

Conclusion: Systolic M-mode annulus excursion showed better inter-observer reproducibility than other traditional and newer measurements of LV systolic and diastolic function. Repeated analyses of the same recordings underestimate the more clinically relevant inter-observer reproducibility by approximately 40% for most measurements of LV function.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Diastole
  • Echocardiography
  • Echocardiography, Doppler
  • Exercise Tolerance
  • Female
  • Heart Ventricles / diagnostic imaging*
  • Humans
  • Male
  • Recovery of Function
  • Reproducibility of Results
  • Statistics as Topic
  • Stroke Volume
  • Systole
  • Ventricular Function, Left