Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

J Hum Hypertens. 2010 Jun;24(6):373-9. doi: 10.1038/jhh.2009.91. Epub 2009 Nov 26.

Abstract

To assess the correlation between endothelial dysfunction and the serum levels of biomarkers of inflammation, remodelling and oxidative stress in essential hypertension, 78 treatment-naïve essential hypertensives (mean age 43 years) underwent measurement of endothelial dysfunction, using the maximal acetylcholine-induced forearm vasodilation and serum levels of adhesion molecules, selectins, chemokines, metalloproteinases, copper, zinc, selenium, vitamins, homocysteine, malondialdehyde, erythrocyte glutathione peroxidase and erythrocyte superoxide dismutase. Mean (+/-s.e.m.) maximal acetylcholine-induced vasodilation was 367+/-20%. Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P=0.009), p-selectin (P<0.001), monocyte chemotactic protein type 1 (MCP-1; P=0.012) and the tissue inhibitor of metalloproteinases type 1 (TIMP-1; P=0.044), which in turn showed significant inverse correlations with maximal endothelium-dependent vasodilation. Serum levels of selenium (P=0.012), vitamin C (P=0.038), erythrocyte glutathione peroxidase (P<0.001) and superoxide dismutase (P=0.022) activities were reduced in patients with a more impaired endothelium-dependent vasodilation. Recently diagnosed treatment-naïve essential hypertensives showed a relationship between the endothelial dysfunction, serum markers of inflammation and remodelling and levels of antioxidant substances. These could be potentially helpful markers of high risk in hypertensive patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology
  • Adult
  • Biomarkers / blood
  • Cell Adhesion Molecules / blood
  • Chemokines / blood
  • Copper / blood
  • Endothelium, Vascular / physiopathology*
  • Female
  • Glutathione Peroxidase / blood
  • Homocysteine / blood
  • Humans
  • Hypertension / blood
  • Hypertension / physiopathology*
  • Male
  • Malondialdehyde / blood
  • Metalloproteases / blood
  • Middle Aged
  • Oxidative Stress
  • Risk Factors
  • Selectins / blood
  • Selenium / blood
  • Superoxide Dismutase / blood
  • Vasculitis / blood
  • Vasculitis / physiopathology*
  • Vasodilation / drug effects*
  • Vitamins / blood
  • Zinc / blood

Substances

  • Biomarkers
  • Cell Adhesion Molecules
  • Chemokines
  • Selectins
  • Vitamins
  • Homocysteine
  • Malondialdehyde
  • Copper
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Metalloproteases
  • Selenium
  • Zinc
  • Acetylcholine