Memory outcome after temporal lobe epilepsy surgery: corticoamygdalohippocampectomy versus selective amygdalohippocampectomy

J Neurosurg. 2010 Dec;113(6):1164-75. doi: 10.3171/2009.10.JNS09677. Epub 2009 Dec 4.


Object: The aim of this study was to compare IQ and memory outcomes at the 1-year follow-up in patients with medically refractory mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis. All patients were treated using a corticoamygdalohippocampectomy (CAH) or a selective amygdalohippocampectomy (SelAH).

Methods: The data of 256 patients who underwent surgery for MTLE were retrospectively evaluated. One hundred twenty-three patients underwent a CAH (63 [right side] and 60 [left side]), and 133 underwent an SelAH (61 [right side] and 72 [left side]). A comprehensive neuropsychological test battery was assessed before and 1 year after surgery, and the results were compared between the surgical procedures. Furthermore, seizure outcome was compared using the Engel classification scheme.

Results: At 1-year follow-up, there was no statistically significant difference between the surgical approaches with respect to seizure outcome. Overall, IQ scores showed improvement, but verbal IQ decreased after left SelAH. Verbal memory impairment was seen after left-sided resections especially in cases of SelAH, and nonverbal memory decreased after right-sided resection, especially for CAH. Left-sided resections produced some improvement in nonverbal memory. Older age at surgery, longer duration of seizures, greater seizure frequency before surgery, and poor seizure control after surgery were associated with poorer memory.

Conclusions: Both CAH and SelAH can lead to several cognitive impairments depending on the side of the surgery. The authors suggest that the optimal type of surgical approach should be decided on a case-by-case basis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anterior Temporal Lobectomy / adverse effects*
  • Anterior Temporal Lobectomy / methods*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology
  • Epilepsy, Temporal Lobe / surgery*
  • Female
  • Humans
  • Intelligence Tests
  • Male
  • Memory Disorders / diagnosis
  • Memory Disorders / etiology*
  • Middle Aged
  • Neuropsychological Tests
  • Neurosurgical Procedures / adverse effects
  • Neurosurgical Procedures / methods
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult