The importance and features of the distal airways in children and adults

J Allergy Clin Immunol. 2009 Dec;124(6 Suppl):S84-7. doi: 10.1016/j.jaci.2009.07.062.


Asthma remains a major problem worldwide, even with new categories of medications that have been brought into the therapeutic armamentarium. One area of disease pathology and physiology that is involved in the pathobiology of asthma is the distal (small) airways. Better understanding of this area in both the pediatric and adult asthmatic populations will lead to improved targeted therapy for all asthmatic patients. This article discusses the importance of the distal airways for both children and adults with asthma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Asthma / drug therapy
  • Asthma / immunology
  • Asthma / physiopathology*
  • Bronchioles* / anatomy & histology
  • Bronchioles* / cytology
  • Bronchioles* / physiopathology
  • Bronchodilator Agents / therapeutic use
  • Child
  • Clinical Trials as Topic
  • Humans
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Inflammation / physiopathology
  • Lung / anatomy & histology
  • Lung / physiopathology
  • Treatment Outcome


  • Bronchodilator Agents