PI3K regulatory subunits lose control in cancer

Cancer Cell. 2009 Dec 8;16(6):449-50. doi: 10.1016/j.ccr.2009.11.017.

Abstract

The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this pathway in cancer.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • Humans
  • Mutation
  • Neoplasms / enzymology*
  • Phosphatidylinositol 3-Kinases / chemistry
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction

Substances

  • Phosphatidylinositol 3-Kinases