Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

Cancer Cell. 2009 Dec 8;16(6):451-2. doi: 10.1016/j.ccr.2009.11.014.


Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.

Publication types

  • Comment

MeSH terms

  • Chromosomal Instability*
  • Genes, Tumor Suppressor*
  • Humans
  • Loss of Heterozygosity*